GTF2E1 Antibody - C-terminal region: Biotin (P100892_P050-Biotin)
Product Specifications
Gene Name
General transcription factor IIE, polypeptide 1, alpha 56kDa
Gene Aliases
FE, TF2E1, TFIIE-A
Gene ID
2960
Swiss Prot
P29083
Accession Number
NP_005504
Host
Rabbit
Reactivity
Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human GTF2E1
Target
The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits of relative molecular mass 57,000 (TFIIE-alpha) and 34,000 (TFIIE-beta) and joins the preinitiation complex after RNA polymerase II and TFIIF. TFIIE-alpha is necessary for transcription initiation together with TFIIE-beta, and recombinant TFIIE-alpha can fully replace the natural subunit in an in vitro transcription assay. Its sequence contains several interesting structural motifs (leucine repeat, zinc finger and helix-turn-helix) and sequence similarities to bacterial sigma factors that suggest direct involvement in the regulation of transcription initiation
Partner Proteins
UBC; AARSD1; ACBD3; XPO5; SH3GLB2; OXR1; NSUN2; RPUSD2; SNF8; EFTUD2; TTC1; SH3GL1; SARS; HARS; SRPK2; TCEA1; GTF2H1; GTF2E2; CDK7; APP; tat; GTF2F1; ELAVL1; ZSCAN1; ZBTB9; TRIM15; PCBD2; TRIM29; CBFA2T2; IKBKG; ATF7IP; TAF6; GTF2B; TRIM24; SND1; GTF2H4
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
49kDa
Shipping Conditions
Wet Ice
Protein Length
439
NCBI Gene Symbol
GTF2E1
Protein Name
General transcription factor IIE subunit 1
Nucleotide Accession Number
NM_005513
Curated Selection
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