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NFKBIL2 Antibody - middle region : Biotin (P100874_P050-Biotin)

Selected Variant

P100874_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Tonsoku-like, DNA repair protein

Gene Aliases

IKBR, SEMDSP, NFKBIL2

Gene ID

4796

Swiss Prot

Q96HA7

Accession Number

NP_038460

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human NFKBIL2

Target

NFKBIL2 is thought to be a negative regulator of NF-kappa-B mediated transcription. It may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.

Partner Proteins

HIST3H3; MCM6; MCM2; MMS22L; ASF1B; ASF1A; UBC; MYC; MAU2; SLC25A5; SUPT16H; SUGT1; AIFM1; HIST1H2BL; XRCC5; SSRP1; SLC25A3; TONSL; MCM4; HIST1H2AE; HIST1H1B; HIST1H1C; XRCC6; GSK3B; MCM7; MCM5; MCM3; EWSR1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Dog: 84%; Human: 100%; Mouse: 83%; Rat: 83%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

133kDa

References & Citations

Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007)

Shipping Conditions

Wet Ice

Protein Length

1219

NCBI Gene Symbol

TONSL

NCBI GB Accession Number

TONSL

Host or Source

Rabbit

Protein Name

Tonsoku-like protein

Nucleotide Accession Number

NM_013432

Peptide Sequence

RAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSR

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