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SRF Antibody - N-terminal region : HRP (P100866_T100-HRP)

Product Specifications

Gene Name

Serum response factor (c-fos serum response element-binding transcription factor)

Gene Aliases

MCM1

Gene ID

6722

Swiss Prot

P11831

Accession Number

NP_003122

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SRF

Target

SRF is a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs) .

Partner Proteins

Camk2d; ZIC3; ELK1; SRFBP1; SRF; NFKB1; PRKDC; CIRBP; ALDH3A1; SUMO1; UBE2I; SHBG; TRIM63; KDM6A; MYOCD; MKL1; CNTN2; CSNK2A1; SMARCA4; PELP1; KAT5; HDAC4; EPC1; SMAD7; HDAC3; MKL2; ATF6; BARX2; MAPKAPK2; FHL3; GATA4; CAMK2A; HOPX; PYCARD; NKX2-3; MINPP1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

CHIP, WB

Sample Type

SRF is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

52kDa

References & Citations

Doi, H., et al., (2005) Arterioscler. Thromb. Vasc. Biol. 25 (11), 2328-2334

Shipping Conditions

Wet Ice

Protein Length

508

NCBI Gene Symbol

SRF

NCBI GB Accession Number

SRF

Host or Source

Rabbit

Protein Name

Serum response factor

Nucleotide Accession Number

NM_003131

Peptide Sequence

ATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIM

Frequently Asked Questions

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