RARA Antibody - middle region : FITC (P100861_P050-FITC)

Product Specifications

Gene Name

Retinoic acid receptor, alpha

Gene Aliases

RAR, NR1B1

Gene ID

5914

Swiss Prot

P10276

Accession Number

NP_000955

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human RARA

Target

Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.

Partner Proteins

NCOR2; NCOR1; RXRG; MED1; HDAC1; NRIP1; TEKT4; NSD1; NCOA1; CEBPA; ITGB1BP2; SUMO1; UBC; MBD3; CBX5; MTA2; E2F1; WWOX; Sumo2; RXRB; RXRA; AKT1; MMS19; Dlg4; TMEM54; FN1; USP7; NCOA2; SUZ12; EZH2; PML; PSMC5; FAS; PRAM1; TBL1XR1; PRAME; ARID5A; UBE3A; UBQL

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB, IHC

Sample Type

RARA is supported by BioGPS gene expression data to be expressed in OVCAR3

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Human: 100%; Mouse: 85%; Rabbit: 100%; Rat: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.