RARA Antibody - middle region : Biotin (P100861_P050-Biotin)
Selected Variant
P100861_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
Retinoic acid receptor, alpha
Gene Aliases
RAR, NR1B1
Gene ID
5914
Swiss Prot
P10276
Accession Number
NP_000955
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human RARA
Target
Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.
Partner Proteins
NCOR2; NCOR1; RXRG; MED1; HDAC1; NRIP1; TEKT4; NSD1; NCOA1; CEBPA; ITGB1BP2; SUMO1; UBC; MBD3; CBX5; MTA2; E2F1; WWOX; Sumo2; RXRB; RXRA; AKT1; MMS19; Dlg4; TMEM54; FN1; USP7; NCOA2; SUZ12; EZH2; PML; PSMC5; FAS; PRAM1; TBL1XR1; PRAME; ARID5A; UBE3A; UBQL
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB, IHC
Sample Type
RARA is supported by BioGPS gene expression data to be expressed in OVCAR3
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Human: 100%; Mouse: 85%; Rabbit: 100%; Rat: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
51kDa
References & Citations
Garapaty, S., (2008) J. Biol. Chem. 283 (11), 6806-6816
Shipping Conditions
Wet Ice
Protein Length
462
NCBI Gene Symbol
RARA
NCBI GB Accession Number
RARA
Host or Source
Rabbit
Protein Name
Retinoic acid receptor alpha
Nucleotide Accession Number
NM_000964
Peptide Sequence
EMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHS
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