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NR2C1 Antibody - C-terminal region : FITC (P100812_T100-FITC)

Product Specifications

Gene Name

Nuclear receptor subfamily 2, group C, member 1

Gene Aliases

TR2

Gene ID

7181

Swiss Prot

Q15625

Accession Number

NP_003288

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human NR2C1

Target

The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites

Partner Proteins

PSPC1; MBD3; SIN3A; RCOR1; KDM1A; POLD3; TRIM28; RBM39; MTA2; MTA1; HDAC3; NR2C2; SMARCA4; SFPQ; RBBP7; RBBP4; NONO; HDAC2; HDAC1; HCFC1; DNMT1; CHD4; NUDT3; UBC; PML; HDAC4; NRIP1; AR; ESR1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Sample Type

There is BioGPS gene expression data showing that NR2C1 is expressed in HCT15

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 100%; Rat: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

67kDa

References & Citations

Li, G., et al., (2003) Biochem. Biophys. Res. Commun. 310 (2), 384-390

Shipping Conditions

Wet Ice

Protein Length

603

NCBI Gene Symbol

NR2C1

NCBI GB Accession Number

NR2C1

Host or Source

Rabbit

Protein Name

Nuclear receptor subfamily 2 group C member 1

Nucleotide Accession Number

NM_003297

Peptide Sequence

QEKAYVEFQDYITKTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLI

Frequently Asked Questions

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