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SMAD6 Antibody - N-terminal region : HRP (P100717_P050-HRP)

Selected Variant

P100717_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

SMAD family member 6

Gene Aliases

AOVD2, MADH6, MADH7, HsT17432

Gene ID

4091

Swiss Prot

O43541

Accession Number

NP_005576

Host

Rabbit

Reactivity

Human, Cow, Dog, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6

Target

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

Partner Proteins

ITCH; SMURF2; BPIFA1; NEDD4L; WWP2; WWP1; USP15; USP11; PIGR; NASP; LYZ; KPNA2; CTBP2; CTBP1; UBC; ACVR1; UBE2O; BAMBI; STAMBP; ACTR1B; TGFBR1; MYD88; SMAD1; BMPR2; BMPR1B; BMPR1A; ACVR2B; ACVR1B; SMURF1; PELI1; CUL2; ELAVL1; SMAD5; RPS6KA5; TSC22D1; MAPK

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Sample Type

There is BioGPS gene expression data showing that SMAD6 is expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 91%; Human: 100%; Pig: 85%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

53kDa

References & Citations

Tsunobuchi, H., et al., (2004) Biophys. Res. Commun. 316 (3), 712-719

Shipping Conditions

Wet Ice

Protein Length

496

NCBI Gene Symbol

SMAD6

NCBI GB Accession Number

SMAD6

Host or Source

Rabbit

Protein Name

Mothers against decapentaplegic homolog 6

Nucleotide Accession Number

NM_005585

Peptide Sequence

GAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKE

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