SMAD6 Antibody - N-terminal region : FITC (P100717_P050-FITC)
Product Specifications
Gene Name
SMAD family member 6
Gene Aliases
AOVD2, MADH6, MADH7, HsT17432
Gene ID
4091
Swiss Prot
O43541
Accession Number
NP_005576
Host
Rabbit
Reactivity
Human, Cow, Dog, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6
Target
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
Partner Proteins
ITCH; SMURF2; BPIFA1; NEDD4L; WWP2; WWP1; USP15; USP11; PIGR; NASP; LYZ; KPNA2; CTBP2; CTBP1; UBC; ACVR1; UBE2O; BAMBI; STAMBP; ACTR1B; TGFBR1; MYD88; SMAD1; BMPR2; BMPR1B; BMPR1A; ACVR2B; ACVR1B; SMURF1; PELI1; CUL2; ELAVL1; SMAD5; RPS6KA5; TSC22D1; MAPK
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Sample Type
There is BioGPS gene expression data showing that SMAD6 is expressed in Jurkat
Concentration
0.5 mg/ml
Homology
Cow: 85%; Dog: 91%; Human: 100%; Pig: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
53kDa
References & Citations
Tsunobuchi, H., et al., (2004) Biophys. Res. Commun. 316 (3), 712-719
Shipping Conditions
Wet Ice
Protein Length
496
NCBI Gene Symbol
SMAD6
NCBI GB Accession Number
SMAD6
Host or Source
Rabbit
Protein Name
Mothers against decapentaplegic homolog 6
Nucleotide Accession Number
NM_005585
Peptide Sequence
GAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKE
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