ELOA Antibody - C-terminal region : FITC (P100692_T100-FITC)
Product Specifications
Gene Name
Elongin A
Gene Aliases
SIII, TCEB3, TCEB3A, SIII p110
Gene ID
6924
Swiss Prot
Q14241
Accession Number
NP_003189
Host
Rabbit
Reactivity
Rat, Dog, Guinea Pig
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human TCEB3
Target
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Partner Proteins
KRTAP10-3; CEP57L1; SPERT; FAM9B; KRT40; CEP70; GMCL1; HOMEZ; TRIM54; MID2; PLK4; JAKMIP2; PSMB9; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; POLR2C; POLR2B; POLR2A; MDFI; UBC; RAD54B; MED26; ECT2; BARD1; CDK12; TCEB2; TCEB1; B
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
IHC, WB
Sample Type
TCEB3 is strongly supported by BioGPS gene expression data to be expressed in HEK293T
Concentration
0.5 mg/ml
Homology
Dog: 100%; Guinea Pig: 91%; Rat: 92%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
87kDa
References & Citations
Beausoleil, S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135
Shipping Conditions
Wet Ice
Protein Length
772
NCBI Gene Symbol
ELOA
NCBI GB Accession Number
ELOA
Host or Source
Rabbit
Protein Name
Elongin-A
Nucleotide Accession Number
NM_003198
Peptide Sequence
AYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR
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