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ELOA Antibody - C-terminal region : Biotin (P100692_T100-Biotin)

Product Specifications

Gene Name

Elongin A

Gene Aliases

SIII, TCEB3, TCEB3A, SIII p110

Gene ID

6924

Swiss Prot

Q14241

Accession Number

NP_003189

Host

Rabbit

Reactivity

Rat, Dog, Guinea Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TCEB3

Target

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

Partner Proteins

KRTAP10-3; CEP57L1; SPERT; FAM9B; KRT40; CEP70; GMCL1; HOMEZ; TRIM54; MID2; PLK4; JAKMIP2; PSMB9; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; POLR2C; POLR2B; POLR2A; MDFI; UBC; RAD54B; MED26; ECT2; BARD1; CDK12; TCEB2; TCEB1; B

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Sample Type

TCEB3 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Dog: 100%; Guinea Pig: 91%; Rat: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

87kDa

References & Citations

Beausoleil, S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135

Shipping Conditions

Wet Ice

Protein Length

772

NCBI Gene Symbol

ELOA

NCBI GB Accession Number

ELOA

Host or Source

Rabbit

Protein Name

Elongin-A

Nucleotide Accession Number

NM_003198

Peptide Sequence

AYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR

Frequently Asked Questions

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