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TMED10 Antibody : HRP (OAPB00473-HRP)

Selected Variant

OAPB00473-100UG-HRP

Size: 0.1 mg

Product Specifications

Gene Name

Transmembrane emp24 domain-containing protein 10

Gene Aliases

P23, TMP21, p24d1, S31I125, Tmp-21-I, S31III125, P24 (DELTA)

Gene ID

10972

Swiss Prot

P49755

Accession Number

NP_006818.3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The immunogen for anti-TMP21 antibody: antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TMP21.

Target

(CT) a component of the presenilin complex

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

ELISA, WB, IHC

Purification

Affinity chromatography purified via peptide column

Concentration

0.6-0.7 mg/ml

Homology

Human; Mouse; Rat

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

References & Citations

Blunt R, Feick P, Puype M, et al. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. J. Biol. Chem.1996; 271:17183-9.; Chen F, Hasegawa H, Schmitt-Ulms G, et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 2006; 440:1208-12.; Periz G and Fortini ME. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, aph-1, and pen-2. J. Neurosci. Res. 2004; 77:309-22. ; Selkoe DJ. The cell biology ofï€ beta-amyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol. 1998; 8:447-53.

Shipping Conditions

Wet Ice

Applications Notes

TMP21 antibody can be used for detection of TMP21 by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)

NCBI Gene Symbol

TMED10

NCBI GB Accession Number

TMED10

Host or Source

Rabbit

Protein Name

Transmembrane emp24 domain-containing protein 10

Nucleotide Accession Number

NM_006827.5

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