NCSTN Antibody : Biotin (OAPB00468-Biotin)
Product Specifications
Gene Name
Nicastrin
Gene Aliases
ATAG1874
Gene ID
23385
Swiss Prot
Q92542
Accession Number
NP_001277113.1NP_001277115.1NP_056146.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The immunogen for anti-Nicastrin antibody: antibody was raised against a 18 amino acid peptide from near the center of human Nicastrin.
Target
(IN) a member of the gamma-secretase complex
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
ELISA, WB, IHC
Purification
Affinity chromatography purified via peptide column
Concentration
1 mg/ml
Homology
Human; Mouse; Rat
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
References & Citations
Weihofen A and Martoglio B. Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. Trends Cell Biol. 2003; 13:71-8.; Periz G and Fortini ME. Functional reconstitution of g-secretase through coordinated expression of presenilin, Nicastrin, aph-1, and pen-2. J. Neurosci. Res. 2004; 77:309-22.; Selkoe DJ. The cell biology of b-amyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol. 1998; 8:447-53.; Nguyen V, Hawkins C, Bergeron C, et al. Loss of nicastrin elicits an apoptotic phenotype in mouse embryos. Brain Res. 2006; 1086:76-84.
Shipping Conditions
Wet Ice
Applications Notes
Nicastrin antibody can be used for detection of Nicastrin by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)
NCBI Gene Symbol
NCSTN
NCBI GB Accession Number
NCSTN
Host or Source
Rabbit
Protein Name
Nicastrin
Nucleotide Accession Number
NM_001290184.1NM_001290186.1NM_015331.2
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