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PSENEN Antibody : HRP (OAPB00465-HRP)

Product Specifications

Gene Name

Gamma-secretase subunit PEN-2

Gene Aliases

PEN2, PEN-2, MDS033, ACNINV2, MSTP064

Gene ID

55851

Swiss Prot

Q9NZ42

Accession Number

NP_001268461.1NP_758844.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The immunogen for anti-PEN2 antibody: antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human PEN2.

Target

(CT) a member of the gamma-secretase complex

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

ELISA, WB, IF

Purification

Affinity chromatography purified via peptide column

Concentration

0.6-0.7 mg/ml

Homology

Human; Mouse; Rat

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

References & Citations

Weihofen A and Martoglio B. Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. Trends Cell Biol. 2003; 13:71-8.; Periz G and Fortini ME. Functional reconstitution of g-secretase through coordinated expression of presenilin, nicastrin, aph-1, and pen-2. J. Neurosci. Res. 2004; 77:309-22.; Selkoe DJ. The cell biology of b-amyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol. 1998; 8:447-53.; Selkoe SJ. Translating cell biology into therapeutic advances in Alzheimer’s disease. Nature 1999; 399:A23-31

Shipping Conditions

Wet Ice

Applications Notes

PEN2 antibody can be used for detection of PEN2 by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)

NCBI Gene Symbol

PSENEN

NCBI GB Accession Number

PSENEN

Host or Source

Rabbit

Protein Name

Gamma-secretase subunit PEN-2

Nucleotide Accession Number

NM_001281532.1NM_172341.2

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