ERN1 Antibody : Biotin (OAPB00365-Biotin)
Product Specifications
Gene Name
Serine/threonine-protein kinase/endoribonuclease IRE1
Gene Aliases
IRE1, IRE1P, IRE1a, hIRE1p
Gene ID
2081
Swiss Prot
O75460
Accession Number
NP_001424.3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The immunogen for anti-IRE1p antibody: antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IRE1p.
Target
(CT) Endoplasmic reticulum-to-nucleus signaling 1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
ELISA, WB, ICC
Purification
Affinity chromatography purified via peptide column
Concentration
1 mg/ml
Homology
Human; Mouse; Rat
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
References & Citations
Little E, Ramakrishnan M, Roy B, et al. The glucose-regulated proteins (GRP78 and GRP94) : functions, gene regulation, and applications. Crit. Rev. Eukaryot. Gene Expr.1994; 4:1-18. ; Lee AS. The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods2005; 35:373-81.; Bertolotti A, Zhang Y, Hendershot LM, et al. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol.2000; 2:326-32.; Shen J, Chen X, Hendershot L, et al. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell2002; 3:99-111.
Shipping Conditions
Wet Ice
Applications Notes
IRE1p antibody can be used for the detection of IRE1p by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
NCBI Gene Symbol
ERN1
NCBI GB Accession Number
ERN1
Host or Source
Rabbit
Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE1
Nucleotide Accession Number
NM_001433.3
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