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IARS Antibody : FITC (OAPB00313-FITC)

Product Specifications

Gene Name

Isoleucine--tRNA ligase, cytoplasmic

Gene Aliases

IRS, IARS, ILRS, ILERS, GRIDHH, PRO0785

Gene ID

3376

Swiss Prot

P41252

Accession Number

NP_002152.2NP_038203.2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The immunogen for anti-IRS-1 antibody: antibody was raised against a 16 amino acid peptide from near the center of human IRS-1.

Target

A scaffolding protein important for insulin receptor signaling

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

ELISA, WB, ICC

Purification

Affinity chromatography purified via peptide column

Concentration

1 mg/ml

Homology

Human; Mouse

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

References & Citations

Giovannone B, Scaldaferri ML, Federici M, et al. Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential. Diabetes Metab. Res. Rev. 2000; 16:434-41.; Waters SB and Pessin JE. Insulin receptor substrate 1 and 2 (IRS1 and IRS2) : what a tangled web we weave. Trends in Cell Biol. 1996; 6:1-4.; Ozes ON, Akca H, Mayo LD, et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl. Acad. Sci. USA 2001; 98:4640-5.; Shamji AF, Ngheim P, and Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol. Cell 2003; 12:271-80.

Shipping Conditions

Wet Ice

Applications Notes

IRS-1antibody can be used for the detection of IRS-1 by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)

NCBI Gene Symbol

IARS

NCBI GB Accession Number

IARS

Host or Source

Rabbit

Protein Name

Isoleucine--tRNA ligase, cytoplasmic

Nucleotide Accession Number

NM_002161.5NM_013417.3

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