Benzyl butyl phthalate

Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) [1][2][3].

Product Specifications

CAS Number

[85-68-7]

UNSPSC

12352005

Hazard Statement

H360

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/benzyl-butyl-phthalate.html

Concentration

10mM

Purity

98.40

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1C(OCC2=CC=CC=C2)=O)OCCCC

Molecular Formula

C19H20O4

Molecular Weight

312.36

Precautions

H360

References & Citations

[1]Sun G, et al. Developmental toxicity and cardiac effects of butyl benzyl phthalate in zebrafish embryos. Aquat Toxicol. 2017;192:165-170.|[2]Cui S, et al. Benzyl butyl phthalate (BBP) triggers the migration and invasion of hemangioma cells via upregulation of Zeb1. Toxicol In Vitro. 2019;60:323-329.|[3]Wang YC, et al. Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling. Oncotarget. 2016;7 (20) :29563-29576.