CASP1 Antibody : HRP (OAPB00287-HRP)
Product Specifications
Gene Name
Caspase-1
Gene Aliases
ICE, P45, IL1BC
Gene ID
834
Swiss Prot
P29466
Accession Number
NP_001214.1NP_001244047.1NP_001244048.1NP_150634.1NP_150635.1NP_150636.1
Host
Rabbit
Reactivity
Human
Immunogen
The immunogen for anti-Caspase-1 antibody: antibody was raised against a 15 amino acid peptide from near the middle of human Caspase-1.
Target
(IN) a caspase in the inflammatory subfamily
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
ELISA, WB, IHC
Purification
Affinity chromatography purified via peptide column
Concentration
0.6-0.7 mg/ml
Homology
Human
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
References & Citations
Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. CCell 2004; 117:561-74.; Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.; Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995; 267:2000-3.; Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.
Shipping Conditions
Wet Ice
Applications Notes
Casp-1 antibody can be used for the detection of Caspase-1 by Western blot at 0.5 ug/ml. Depending on cell lines or tissues used, other cleavage products may be observed. (Optimal dilution should be determined by user)
NCBI Gene Symbol
CASP1
NCBI GB Accession Number
CASP1
Host or Source
Rabbit
Protein Name
Caspase-1
Nucleotide Accession Number
NM_001223.4NM_001257118.2NM_001257119.2NM_033292.3NM_033293.3NM_033294.3
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