CYP1A2 Antibody: HRP (OABF01032-HRP)
Product Specifications
Gene Name
Cytochrome P450, family 1, subfamily A, polypeptide 2
Gene Aliases
CP12, CYPIA2, P3-450, P450 (PA)
Gene ID
1544
Swiss Prot
P05177
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated synthetic peptide derived from human Cytochrome P450 1A2
Target
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB, IHC-P, IF
Purification
Purified by Protein A.
Concentration
0.6-0.7 mg/mL
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Shipping Conditions
Wet Ice
Fragment
IgG
NCBI Gene Symbol
CYP1A2
Curated Selection
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