Sorbinil

Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway[1][2].

Product Specifications

CAS Number

[68367-52-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sorbinil.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@]12C3=CC(F)=CC=C3OCC1)NC(N2)=O

Molecular Formula

C11H9FN2O3

Molecular Weight

236.20

Precautions

H302

References & Citations

[1]Huang Q, et al. Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. Med Chem. 2019;15 (1) :3-7.|[2]Chang KC, et al. Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact. 2013 Feb 25;202 (1-3) :283-7.