Z-LEHD-FMK (TFA)
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3].
Product Specifications
CAS Number
524746-03-0
UNSPSC
12352209
Target
Apoptosis; Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/z-lehd-fmk-tfa.html
Solubility
H2O
Smiles
OC(C(F)(F)F)=O.O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CCC(OC)=O)C(N[C@H](C(N[C@H](C(CF)=O)CC(OC)=O)=O)CC2=CN=CN2)=O)=O
Molecular Formula
C34H44F4N6O12
Molecular Weight
804.74
References & Citations
[1]Ozoren N, et, al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Nov 15; 60 (22) : 6259-65.|[2]Colak A, et, al. Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. J Neurosurg Spine. 2005 Mar; 2 (3) : 327-34.|[3]Mocanu MM, et, al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May; 130 (2) : 197-200.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 9
Citation 01
MSphere. 2024 May 17:e0023624.|Preprints. 2024 Aug 14.|Virol Sin. 2024 May 30:S1995-820X (24) 00078-6.|Cell Mol Life Sci. 2025 Nov 19;82 (1) :408.|Cell Rep. 2025 Mar 25;44 (4) :115462.|Chem Biol Interact. 2025 Oct 22:420:111693.|Food Chem Toxicol. 2018 Oct:120:143-154.|Food Chem Toxicol. 2019 Oct:132:110655.|Food Chem Toxicol. 2020 Dec;146:111843.|Infect Immun. 2025 Aug 12;93 (8) :e0015825.|J Cell Mol Med. 2019 Apr;23 (4) :2489-2504.|J Cell Mol Med. 2020 Jul;24 (14) :8151-8165.|Oxid Med Cell Longev. 2022 Jun 26:2022:2912276.|Sci Adv. 2023 Oct 6;9 (40) :eadi6586.|SSRN. 2025 Oct 15.
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