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EIF2AK2 Antibody - C-terminal region : HRP (AVARP09033_P050-HRP)

Selected Variant

AVARP09033_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Eukaryotic translation initiation factor 2-alpha kinase 2

Gene Aliases

PKR, PRKR, LEUDEN, EIF2AK1, PPP1R83

Gene ID

5610

Swiss Prot

P19525

Accession Number

NP_002750

Host

Rabbit

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human EIF2AK2

Target

EIF2AK2 might play a role in ER stress-induced apoptosis and in Alzheimer's disease. Alzheimer cases show prominent EIF2AK2 activation in association with neuritic plaques and pyramidal neurons in the hippocampus and neocortex.

Partner Proteins

UBC; TRAF6; TRAF5; TRAF2; EGFR; DHX9; STAU2; PRKRA; EIF2AK2; HECW2; TOP1; STAU1; DICER1; DHX30; EBNA1BP2; IGF2BP2; IGF2BP3; PABPC4; MOV10; ILF3; ILF2; HSP90AA1; EIF2A; NOC3L; GNL3; NOP2; HNRNPC; HIST1H1C; ELAVL1; NPM1; IL7R; gag; Jak2; TYK2; JAK1; EIF2S1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Human: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

62kDa

References & Citations

Alisi, A., et al., (2005) J Cell Physiol. 205 (1), 25-31

Shipping Conditions

Wet Ice

Protein Length

551

NCBI Gene Symbol

EIF2AK2

NCBI GB Accession Number

EIF2AK2

Host or Source

Rabbit

Protein Name

Interferon-induced, double-stranded RNA-activated protein kinase

Nucleotide Accession Number

NM_002759

Peptide Sequence

IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC

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