E2F1 Antibody - C-terminal region : Biotin (AVARP04006_P050-Biotin)
Product Specifications
Gene Name
E2F transcription factor 1
Gene Aliases
RBP3, E2F-1, RBAP1, RBBP3
Gene ID
1869
Swiss Prot
Q01094
Accession Number
NP_005216
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human E2F1
Target
The protein encoded by E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Partner Proteins
RB1; SIRT1; KDM2A; LAMTOR5; EP300; KAT2B; VHL; RARA; STAT1; NCOR2; STOML1; RBL1; MAGEA11; SKP2; UHRF2; UBC; GTF2H1; ERCC3; SPT15; TFB1; TBP; NCOA3; CEBPE; PARP1; PRMT2; RBL2; CCNE1; TFDP2; TFDP1; CDKN2A; CEBPD; CDK2; CDK1; NEDD8; MCPH1; DDB2; DDB1; XIAP
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Sample Type
E2F1 is strongly supported by BioGPS gene expression data to be expressed in Daudi
Concentration
0.5 mg/ml
Homology
Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
47kDa
References & Citations
Unoki, M., et al., (2004) Oncogene 23 (46), 7601-7610
Shipping Conditions
Wet Ice
Protein Length
437
NCBI Gene Symbol
E2F1
NCBI GB Accession Number
E2F1
Host or Source
Rabbit
Protein Name
Transcription factor E2F1
Nucleotide Accession Number
NM_005225
Peptide Sequence
REDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF
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