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CDKN2B Antibody - middle region : HRP (AVARP03047_P050-HRP)

Selected Variant

AVARP03047_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Gene Aliases

P15, MTS2, TP15, CDK4I, INK4B, p15INK4b

Gene ID

1030

Swiss Prot

P42772

Accession Number

NP_004927

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CDKN2B

Target

CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.

Partner Proteins

UBC; TRAF1; CDK6; CCDC33; NIF3L1; CDK4; PYCRL; RNF20; TGFB1I1; ISL1; APP; KIAA1377; CCDC90B; ARPC3; ZBTB17; IKBKAP; CDK8; MAGEA11; PIAS2

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Dog: 91%; Guinea Pig: 83%; Mouse: 83%; Pig: 100%; Rabbit: 91%; Rat: 83%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

15kDa

References & Citations

Scott, S.A., et al., (2004) Leuk. Res. 28 (12), 1293-1301

Shipping Conditions

Wet Ice

Protein Length

138

NCBI Gene Symbol

CDKN2B

NCBI GB Accession Number

CDKN2B

Host or Source

Rabbit

Protein Name

Cyclin-dependent kinase 4 inhibitor B

Nucleotide Accession Number

NM_004936

Peptide Sequence

REGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD

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