CDC25C Antibody - N-terminal region : Biotin (AVARP03034_P050-Biotin)
Product Specifications
Gene Name
Cell division cycle 25 homolog C (S. pombe)
Gene Aliases
CDC25, PPP1R60
Gene ID
995
Swiss Prot
P30307
Accession Number
NP_073720
Host
Rabbit
Reactivity
Human, Mouse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human CDC25C
Target
CDC25C gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
Partner Proteins
CDC37; UBC; HSP90AA1; HSPA4; YWHAB; YWHAQ; YWHAZ; YWHAH; YWHAG; YWHAE; PKN1; SFN; MAPK9; PLK1; CHEK1; CHEK2; CDS1; MARK3; BRSK2; CDK2; PCNA; Cdk1; USP17L2; MAPK3; MAPK1; BRSK1; LZTS1; PLK3; NEDD4; PIN1; MAPK14; TP53; HRAS; LCK; CCNB1; CCNA2; SRC; SP1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Sample Type
There is BioGPS gene expression data showing that CDC25C is expressed in Jurkat
Concentration
0.5 mg/ml
Homology
Human: 100%; Mouse: 91%; Rabbit: 83%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
45kDa
References & Citations
Bonnet, J., (2008) Biochem. Biophys. Res. Commun. 370 (3), 483-488
Shipping Conditions
Wet Ice
Protein Length
400
NCBI Gene Symbol
CDC25C
NCBI GB Accession Number
CDC25C
Host or Source
Rabbit
Protein Name
M-phase inducer phosphatase 3
Nucleotide Accession Number
NM_022809
Peptide Sequence
QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALRE
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