CDK6 Antibody - C-terminal region : HRP (AVARP03005_T100-HRP)

Product Specifications

Gene Name

Cyclin-dependent kinase 6

Gene Aliases

MCPH12, PLSTIRE

Gene ID

1021

Swiss Prot

Q00534

Accession Number

NP_001250

Host

Rabbit

Reactivity

Human, Mouse, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CDK6

Target

CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

Partner Proteins

PSMA3; DAB1; CDKN2D; CDKN2C; CDKN2B; CCND3; UBC; CCND2; AMY2A; CDKN2A; CDK6; PIGR; DMBT1; WDR33; CDKL3; RB1; CDK4; UCHL1; PML; NUMA1; NFATC3; MYC; MLLT3; MEF2D; MCM2; ISL1; HSP90AA1; HSF1; FOXO3; FOXM1; EZH2; ELK1; DDIT3; ATF6B; CDKN1A; CDC6; CCND1; ZSCAN

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

Sample Type

CDK6 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 84%; Dog: 84%; Horse: 84%; Human: 100%; Mouse: 76%; Pig: 84%; Rabbit: 84%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.