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TIAL1 Antibody - C-terminal region : Biotin (AVARP02048_T100-Biotin)

Product Specifications

Gene Name

TIA1 cytotoxic granule-associated RNA binding protein-like 1

Gene Aliases

TCBP, TIAR

Gene ID

7073

Swiss Prot

Q01085

Accession Number

NP_003243

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TIAL1

Target

The protein encoded by TIAL1 is a member of a family of RNA-binding proteins and possesses nucleolytic activity against cytotoxic lymphocyte target cells. The gene product is a cytotoxic granule-associated protein and has been shown to bind specifically to poly (A) homopolymers and to fragment DNA in permeabilized target cells. It has been suggested that members of this protein family may be involved in the induction of apoptosis. One isoform contains a lysosome-targeting motif in its C-terminal auxiliary domain; however, alternative splicing results in a T-cluster DNA-binding isoform, differing at the C-terminus where a hydrophobic sequence replaces the lysosome-targeting motif.

Partner Proteins

SUMO2; UBC; RPA3; RPA2; RPA1; BMI1; SOX2; MAPK1; GADD45A; VCAM1; ITGA4; FN1; MRPL53; SARNP; UFM1; SBDS; MRPS28; TOMM40; ACAA2; GNB2L1; SF3B4; SCAMP3; SCO2; ALDH5A1; VDAC1; UBE2D2; THY1; SOD1; MBNL1; CAND1; DCUN1D1; COPS5; COPS6; CUL1; CUL2; CUL3; CUL4A; C

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Sample Type

TIAL1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 85%; Rabbit: 100%; Rat: 85%; Zebrafish: 76%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

42kDa

References & Citations

Esclatine, A., et al., (2004) J. Virol. 78 (16), 8582-8592

Shipping Conditions

Wet Ice

Protein Length

375

NCBI Gene Symbol

TIAL1

NCBI GB Accession Number

TIAL1

Host or Source

Rabbit

Protein Name

Nucleolysin TIAR

Nucleotide Accession Number

NM_003252

Peptide Sequence

WNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ

Frequently Asked Questions

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