BAX Antibody - N-terminal region : FITC (AVARP02020_T100-FITC)
Product Specifications
Gene Name
BCL2-associated X protein
Gene Aliases
BCL2L4
Gene ID
581
Swiss Prot
Q07812
Accession Number
NP_620116
Host
Rabbit
Reactivity
Human, Cow, Dog, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human BAX
Target
BAX encodes a protein that belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. BAX expression is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.
Partner Proteins
CYCS; ZBTB24; UBC; CASP9; CASP8; CASP7; CASP3; BCL2L1; BCL2; CLU; MDM2; MCL1; BAX; BAG3; YWHAB; VCP; CRYAB; CRYAA; BAK1; XIAP; TP53; KCNA3; HSPA4; XRCC6; XRCC5; HDAC6; BAD; PSMC5; PSMC3; PARK7; UHRF2; RNF144B; OYE2; TOMM22; TOMM40; MEPCE; MOAP1; BBC3; PPP
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
IHC, WB
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Human: 100%; Pig: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
21kDa
References & Citations
Yamaguchi, H., et al., (2004) J. Biol. Chem. 279 (38), 39431-39437
Shipping Conditions
Wet Ice
Product Datasheet
Anti-BAX (AVARP02020_T100-FITC) antibody
Protein Length
192
NCBI Gene Symbol
BAX
NCBI GB Accession Number
BAX
Host or Source
Rabbit
Protein Name
Apoptosis regulator BAX
Nucleotide Accession Number
NM_138761
Peptide Sequence
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPV
Curated Selection
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