TRADD Antibody - middle region : HRP (AVARP02012_P050-HRP)

Product Specifications

Gene Name

TNFRSF1A-associated via death domain

Gene Aliases

Hs.89862

Gene ID

8717

Swiss Prot

Q15628

Accession Number

NP_003780

Host

Rabbit

Reactivity

Human, Dog, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TRADD

Target

TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

FADD; UBC; TNF; RIPK1; TNFRSF1A; ZMYND11; TOMM70A; PDLIM7; LRRK2; OPTN; TRADD; TRAF2; TRAF1; TNFRSF1B; GFRA1; CHUK; FAS; DAB2IP; EDAR; CDKN2A; TRIP12; LMP1; CASP8; SH3KBP1; USP2; TNFRSF25; PPP2R1A; TRPC4AP; HIPK2; TNFRSF21; CNTRL; TNFRSF10B; TNFRSF10A; BC

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

Sample Type

There is BioGPS gene expression data showing that TRADD is expressed in DU145, HEK293T

Concentration

0.5 mg/ml

Homology

Dog: 76%; Horse: 76%; Human: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.