CFLAR Antibody - C-terminal region : Biotin (AVARP02011_P050-Biotin)
Product Specifications
Gene Name
CASP8 and FADD-like apoptosis regulator
Gene Aliases
CASH, FLIP, MRIT, CLARP, FLAME, cFLIP, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1
Gene ID
8837
Swiss Prot
O15519
Accession Number
NP_003870
Host
Rabbit
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of human CFLAR
Target
CFLAR belongs to the peptidase C14A family. It is a apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. The protein acts as an inhibitor of TNFRSF6 mediated apoptosis. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity.
Partner Proteins
FADD; TRAF1; GSN; SPATS1; TNFSF10; RIPK1; RAF1; SMAD3; CASP8; HSP90AA1; STUB1; TNFRSF10A; TNFRSF10B; UBC; FASLG; ITCH; DAXX; CBLB; ATG3; XRCC6; Mib1; TP53; DEDD2; DEDD; RIPK2; IKBKB; MAP2K7; TRAF2; CASP10; CASP7; CASP6; MAP2K4; PSEN2; CASP2; CASP3; BCL2L1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Sample Type
CFLAR is strongly supported by BioGPS gene expression data to be expressed in 721_B
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
55kDa
References & Citations
Geserick, P., (2008) Oncogene 27 (22), 3211-3220
Shipping Conditions
Wet Ice
Protein Length
480
NCBI Gene Symbol
CFLAR
NCBI GB Accession Number
CFLAR
Host or Source
Rabbit
Protein Name
CASP8 and FADD-like apoptosis regulator
Nucleotide Accession Number
NM_003879
Peptide Sequence
LRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400030-500 1x 500 µL
Insulin (2D11-H5), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940158-500 1x 500 µL
Cytokeratin 17 (E3), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882216-500 1x 500 µL
CD50 / ICAM3 (CG106), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 