CFLAR Antibody - C-terminal region : Biotin (AVARP02011_P050-Biotin)

Product Specifications

Gene Name

CASP8 and FADD-like apoptosis regulator

Gene Aliases

CASH, FLIP, MRIT, CLARP, FLAME, cFLIP, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1

Gene ID

8837

Swiss Prot

O15519

Accession Number

NP_003870

Host

Rabbit

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of human CFLAR

Target

CFLAR belongs to the peptidase C14A family. It is a apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. The protein acts as an inhibitor of TNFRSF6 mediated apoptosis. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity.

Partner Proteins

FADD; TRAF1; GSN; SPATS1; TNFSF10; RIPK1; RAF1; SMAD3; CASP8; HSP90AA1; STUB1; TNFRSF10A; TNFRSF10B; UBC; FASLG; ITCH; DAXX; CBLB; ATG3; XRCC6; Mib1; TP53; DEDD2; DEDD; RIPK2; IKBKB; MAP2K7; TRAF2; CASP10; CASP7; CASP6; MAP2K4; PSEN2; CASP2; CASP3; BCL2L1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Sample Type

CFLAR is strongly supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Human: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.