FOXO4 Antibody - middle region : FITC (AVARP01018_P050-FITC)
Product Specifications
Gene Name
Forkhead box O4
Gene Aliases
AFX, AFX1, MLLT7
Gene ID
4303
Swiss Prot
P98177
Accession Number
NP_005929
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human FOXO4
Target
FOXO4 is transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The protein can down-regulate expression of HIF1A and suppress hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias.
Partner Proteins
REL; SFN; AKT1; OGT; UBC; ATXN3; MDM2; NLK; USP7; CTNNB1; CREBBP; VDR; SIRT1; SMAD3; XPO1; YWHAZ; SMAD4; FOXG1; AKT2; ESR1; PIN1; CCND1; CDKN1A
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/ml
Homology
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
54kDa
References & Citations
Boura, E., (2007) J. Biol. Chem. 282 (11), 8265-8275
Shipping Conditions
Wet Ice
Protein Length
505
NCBI Gene Symbol
FOXO4
NCBI GB Accession Number
FOXO4
Host or Source
Rabbit
Protein Name
Forkhead box protein O4
Nucleotide Accession Number
NM_005938
Peptide Sequence
YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI
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