FADD Antibody - C-terminal region : Biotin (AVARP01012_P050-Biotin)

The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.

CFLAR; CASP10; CASP8; ATG5; ATG12; TNF; TRADD; UBC; RIPK1; FAS; TNFSF10; SPOP; TNFRSF1A; MYD88; TNFRSF10A; TNFRSF10B; MKRN1; RIPK3; CUL3; TRAF2; PARK7; FASLG; LRRK2; IKBKG; BMX; FAF1; EDAR; DAPK1; CLIP3; DAXX; TNFAIP3; MAVS; KHDRBS1; TAB1; EZR; TRIM21; IR

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.