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TNFRSF11B Antibody - N-terminal region : Biotin (AVARP00033_T100-Biotin)

Selected Variant

AVARP00033_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

Tumor necrosis factor receptor superfamily, member 11b

Gene Aliases

OPG, TR1, OCIF, PDB5

Gene ID

4982

Swiss Prot

O00300

Accession Number

NP_002537

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human TNFRSF11B

Target

TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Partner Proteins

TNFSF13; TNFSF10; TNFSF11; VWF; VTN; THBS1; FN1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Dog: 78%; Horse: 78%; Human: 100%; Mouse: 85%; Pig: 78%; Rabbit: 78%; Rat: 78%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

46kDa

References & Citations

Cross, S.S., et al., (2006) Int. J. Cancer 118 (8), 1901-1908

Shipping Conditions

Wet Ice

Protein Length

401

NCBI Gene Symbol

TNFRSF11B

NCBI GB Accession Number

TNFRSF11B

Host or Source

Rabbit

Protein Name

Tumor necrosis factor receptor superfamily member 11B

Nucleotide Accession Number

NM_002546

Peptide Sequence

LDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTV

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