NLRC4 Antibody - C-terminal region : Biotin (AVARP00019_P050-Biotin)

Product Specifications

Gene Name

NLR family, CARD domain containing 4

Gene Aliases

CLAN, IPAF, AIFEC, CLAN1, CLANA, CLANB, CLANC, CLAND, FCAS4, CARD12, CLR2.1

Gene ID

58484

Swiss Prot

Q9NPP4

Accession Number

NP_067032

Host

Rabbit

Reactivity

Human, Mouse, Rat, Guinea Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human NLRC4

Target

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs) . Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs) . CARD12 is a member of the Ced4 family and can induce apoptosis.

Partner Proteins

UBC; XK; ALB; NLRC4; PSMC5; CASP8; NLRP4; PYCARD; NOD2; BCL10; CASP1; NLRP1; NLRP3; NOD1; NAIP

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Guinea Pig: 80%; Human: 100%; Mouse: 86%; Rat: 80%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

116kDa

References & Citations

Clark, H.F., et al., (2003) Genome Res. 13 (10), 2265-2270

Shipping Conditions

Wet Ice

Specificity

This antibody will recognize NLRC4 isoform 1 (116kD) and isoform 2 (40kD) .

Protein Length

1024

NCBI Gene Symbol

NLRC4

NCBI GB Accession Number

NLRC4

Host or Source

Rabbit

Protein Name

NLR family CARD domain-containing protein 4

Nucleotide Accession Number

NM_021209

Peptide Sequence

QLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQV

More Discoveries

Explore Other Products

Browse additional items from our catalog

505004 Inquire

5α-ANDROSTAN-3α-OL-17-ONE SULPHATE, SODIUM SALT-16,16 -d2

View Details

NBP2-81966R 0.1 mL

Rabbit Polyclonal MTERFD2 Antibody [DyLight 550]

View Details

PVT72790 2 µg

PU6-DEK-sgRNA2-Cas9-EGFP Plasmid

View Details

MBS6333917-01 0.2 mL

PIGV, CT (PIGV, GPI mannosyltransferase 2, GPI mannosyltransferase II, Phosphatidylinositol-glycan biosynthesis class V protein) (Biotin)

View Details

MBS6333917-02 5x 0.2 mL

PIGV, CT (PIGV, GPI mannosyltransferase 2, GPI mannosyltransferase II, Phosphatidylinositol-glycan biosynthesis class V protein) (Biotin)

View Details

BS45959-01 50 µL

CHD3 Recombinant Rabbit mAb

View Details