UIMC1 Antibody - middle region : Biotin (ARP75596_P050-Biotin)

UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) . The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

HIST2H2AC; UBC; FANCG; RPS6; HSPA4; CDK1; C1QBP; BRCA1; FAM175A; BRCC3; ELC1; ELA1; BLM; SKIL; SUMO1; SUMO2; MDC1; PAXIP1; Cep57; BRE; HIST2H2BE; ESR1; ATP8A2; KIAA0368; RBBP8; RAD23A; BABAM1; TP53; MDM2; SSU72; FAM175B; ERP44; G3BP1; G3BP2; SPATA2; BAG5

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.