SF3B2 Antibody - middle region : FITC (ARP75393_P050-FITC)

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP) . The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.

SF3B4; TP53; STAU1; UBC; LIN28A; MDM2; RPA3; RPA2; RPA1; ERG; WWOX; SUZ12; RNF2; EZH2; PRPF40A; KDM1A; TCERG1; APBB1; FBXO6; HDAC11; DHX16; ZCCHC10; LSM3; SNRNP200; PRPF8; SLU7; RBM7; THOC1; RBM8A; PRPF3; Dlg4; TTC14; FRA10AC1; TOE1; ZNF830; LSM2; XAB2; U

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.