PDCD6IP Antibody - C-terminal region : FITC (ARP75320_P050-FITC)

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

UBI4; CEP55; UBC; SUMO2; nef; EZH2; IPO9; UBA6; MCTS1; AHCYL1; EZR; UBA1; MAPK1; CHMP4B; gag; UBD; BAG3; RNF11; KEAP1; VCAM1; SH3GL1; CHMP4C; TNIP2; ITGA4; CXCR1; GRB2; HOXA1; PEF1; VPS4B; ABCC1; GPI; PDCD6; F2R; CUL3; ALG2; PTK2B; TUBB; SIRT7; SH3KBP1; C

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.