MDM2 Antibody - middle region : FITC (ARP74981_P050-FITC)

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

RPS7; RPS6; RPL26; UBE2D3; UBE2D2; UBE2D1; UBC; CDKN2A; HDAC1; TSC22D3; DAPK3; PARP1; PML; ARIH2; RPL23; KAT2B; AATF; RCHY1; DLAT; DHX9; DDX5; DAXX; U19; HRNR; OGDH; NCL; HNRNPM; MDM4; MDM2; ILF3; IFI16; IARS; HSP90AB1; HSP90AA1; HSPA8; HNRNPU; GTF2I; PER

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.