LMNA Antibody - C-terminal region: FITC (ARP74976_P050-FITC)

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

LMNA; RAPGEF2; FUS; KRTAP10-3; KRTAP10-7; DUSP13; UBC; TP53; SUMO2; SUMO3; MDM2; EED; KIAA0196; ROCK2; ZW10; NCL; EEF1D; PSMD10; GMPPB; KPNA6; KCTD12; PARK2; FBXO6; YWHAQ; ZNF280C; PGRMC2; SCML2; HNRNPR; TRIM28; ZBTB33; NUP153; THRAP3; USP15; POM121; DDX4

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.