HRAS Antibody - C-terminal region : Biotin (ARP74951_P050-Biotin)

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

RIN1; LGALS1; ABL2; DAB2IP; RASSF5; RAF1; KRT18; SLC9A3R2; TPR; PSMB2; NEDD8; ZHX2; LATS2; PPP1R13B; TP53; RNF115; BRAP; CBL; SPRY2; UBC; SH3KBP1; RABGEF1; BTRC; DEAF1; RGL1; RALGDS; RGL2; GRIN1; ZBTB12; RIT2; RASSF2; RASIP1; TTC1; RAP1GDS1; RGL4; RASGRP4

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.