ATF2 Antibody - C-terminal region : Biotin (ARP74400_P050-Biotin)

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene.

MAPK10; MAPK9; MAPK8; MAPK1; SUMO1; KIFC3; FOS; MAPK14; EXOSC8; JUN; CREBBP; ATF2; CEBPG; BACH1; ATF4; ATF3; BATF3; DDIT3; BATF; FOSL1; H2AFY; RB1; GAPDH; NME2P1; TUBB; SFXN1; RAB2B; TMX1; GRPEL1; COLGALT1; AHNAK; SQRDL; RTN4; APMAP; C19orf10; RAB14; ERO1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.