CEP57 Antibody - middle region : FITC (ARP73881_P050-FITC)

This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

MAGEA2B; KRT40; CEP63; GCC1; TFIP11; RALBP1; CTAGE5; KRT31; KRT15; KRT13; RPS15P2; TCEB1P3; RPL27AP6; HRNR; HNRNPUL2; MYL6B; HINT3; LRCH3; CCDC8; GRWD1; CEP290; CCDC33; MRPL40; MRPS11; LY6G5B; ATAD3A; TRMT10C; CPVL; MRPS23; FAM96B; MRPS7; PRPF19; LSM3; CP

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.