FBXW5 Antibody - N-terminal region : HRP (ARP73235_P050-HRP)

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

KRT40; KRTAP9-4; ADAMTSL4; CUL1; UBC; TRIM27; KRT31; NOTCH2NL; KRTAP10-3; KRTAP10-8; CUL3; SKP1; TNFAIP8L1; TSC2; DLC1; HSP90AA1; NEDD8; MAP3K7; CUL4A; REST; MYB; DDB1; UBE2R2; SASS6; PLK4; CDC20; WDR20; KRTAP4-12; MDFI; TSC1; NLK

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.