Voriconazole-d3

Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].

Product Specifications

CAS Number

[1217661-14-7]

Product Name Alternative

UK-109496-d3

UNSPSC

12352005

Hazard Statement

H301, H351, H360, H412

Target

Fungal

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection

Field of Research

Infection

Purity

99.90

Solubility

10 mM in DMSO|DMSO : ≥ 50mg/mL|H2O : 0.17mg/mL (ultrasonic)

Smiles

[2H]C([2H])([2H])[C@@H](C1=NC=NC=C1F)[C@@](O)(C2=C(C=C(C=C2)F)F)CN3C=NC=N3

Molecular Formula

C16H11D3F3N5O

Molecular Weight

352.33

Precautions

H301, H351, H360, H412

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Nickie D Greer. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent) . 2003 Apr;16 (2) :241-8.|[3]Lesley J Scott, et al. Voriconazole : a review of its use in the management of invasive fungal infections.Drugs. 2007;67 (2) :269-98.|[4]A M Sugar, et al. Efficacy of voriconazole in treatment of murine pulmonary blastomycosis.Antimicrob Agents Chemother. 2001 Feb;45 (2) :601-4.