KDM5B Antibody - C-terminal region : Biotin (ARP72851_P050-Biotin)

KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.

FBXW11; UBC; HDAC2; HDAC4; SUMO1; SUMO3; PPP1CA; TFAP2C; MYC; HDAC7; HDAC5; NCOR1; PAX9; HDAC1; ELAVL1; CHD3; MTA3; MBD3; KDM1A; MTA2; MBD2; RBBP7; RBBP4; RB1; SUMO2; KLF10; LMO2; FOXG1; AR; VGLL3; PRDM13; ARID1B; BMP2K; RNF43; RBM15B; DBNL; CECR6; SLC39A

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.