MAP3K7 Antibody - C-terminal region : FITC (ARP72678_P050-FITC)

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

MAGED1; UBC; TRAF6; HSPB1; TAB2; IKBKB; TRAF4; TGFBR1; MAP3K7; MAP2K6; MAPK8; NAIP; XIAP; RIPK1; TIRAP; TAB1; SIK1; SIK3; SYK; SASH1; IRAK1; TNFRSF1A; MAPK8IP1; RIPK2; IKBKG; VRK2; MAP2K4; NOD2; PRKCQ; PPM1L; SKIL; PPP6C; PPP2R1A; MAP3K3; BST2; PINK1; MAL

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.