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NSMCE4A Antibody - C-terminal region : FITC (ARP70963_P050-FITC)

Selected Variant

ARP70963_P050-FITC

Size: 100 µL

Product Specifications

Gene Aliases

NS4EA, NSE4A, C10orf86

Gene ID

54780

Swiss Prot

Q9NXX6

Accession Number

NP_060085

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human NSMCE4A

Target

NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . It is involved in positive regulation of response to DNA damage stimulus.

Partner Proteins

UBC; HECW2; SRPK2; SRPK1; MAGED4B; NDNL2; MAGEC2; MAGEH1; MAGED2; NDN; MAGEB1; MAGEA1; NSMCE1; SMC6

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IF, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

44kDa

Shipping Conditions

Wet Ice

Protein Length

385

NCBI Gene Symbol

NSMCE4A

NCBI GB Accession Number

NSMCE4A

Host or Source

Rabbit

Protein Name

Non-structural maintenance of chromosomes element 4 homolog A

Nucleotide Accession Number

NM_017615

Peptide Sequence

PVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFF

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