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OTULIN Antibody - C-terminal region : FITC (ARP70290_P050-FITC)

Selected Variant

ARP70290_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

OTU deubiquitinase with linear linkage specificity

Gene Aliases

GUM, AIPDS, FAM105B

Gene ID

90268

Swiss Prot

Q96BN8

Accession Number

NP_612357

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human FAM105B

Target

This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1 (Met1) -linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients.

Partner Proteins

FAM168A; DAZAP2; UBC; SHARPIN; RNF31; RBCK1; VCP; TNF; DVL2; DSTN; CUL4A; ELAVL1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 85%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

38kDa

Shipping Conditions

Wet Ice

Protein Length

352

NCBI Gene Symbol

OTULIN

NCBI GB Accession Number

OTULIN

Host or Source

Rabbit

Protein Name

Ubiquitin thioesterase otulin

Nucleotide Accession Number

NM_138348

Peptide Sequence

NRAIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLE

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