EIF5A Antibody - N-terminal region : Biotin (ARP70188_P050-Biotin)

EIF5A is a mRNA-binding protein involved in translation elongation. It has an important function at the level of mRNA turnover, probably acting downstream of decapping. It is involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, EIF5A functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. EIF5A regulates also TNF-alpha-mediated apoptosis and mediates effects of polyamines on neuronal process extension and survival. It may play an important role in brain development and function, and in skeletal muscle stem cell differentiation. EIF5A is also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

HUWE1; UBC; REL; MEOX2; DHPS; CRX; DCP2; STUB1; BCCIP; WDR1; GDA; TYMS; PEPD; MVD; HSPD1; GNS; GLS; UBD; NPM1; IQCB1; ATF2; VCP; MACF1; DDX17; VAPA; XPO1; ATP5B; XPO4; CUL2; COPS5; TCF3; ELAVL1; SUMO2; VHL; Pds5a; Csnk1e; DOHH; XRN2; RPL5; TGM2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.