SPRTN Antibody - middle region : HRP (ARP68995_P050-HRP)
Product Specifications
Gene Aliases
DVC1, PRO4323, spartan, C1orf124
Gene ID
83932
Swiss Prot
Q9H040
Accession Number
NP_114407
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human SPRTN
Target
SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Partner Proteins
H2BFS; UBR5; FAM120A; STRAP; CKAP4; MAGED2; HIST2H2BF; HIST1H2BK; POLD4; ZC3HAV1; POLD3; DDX17; SYNCRIP; TRIM28; LRPPRC; HUWE1; HNRNPDL; AKAP12; RBM39; H1FX; HIST1H2BH; HIST1H2BM; HIST1H2BN; HIST1H2BL; HIST1H2BG; VIM; VDAC1; UBB; TUFM; DNAJC7; TMPO; STAU1
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 92%; Rat: 100%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
55kDa
Shipping Conditions
Wet Ice
Protein Length
489
NCBI Gene Symbol
SPRTN
NCBI GB Accession Number
SPRTN
Host or Source
Rabbit
Protein Name
SprT-like domain-containing protein Spartan
Nucleotide Accession Number
NM_032018
Peptide Sequence
ATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLA
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